PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function

PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function

Abstract Background Abnormal neovascularization is the most common cause of blindness, and hypoxia alters tissue metabolism, function, and morphology. HIF-1α, the transcriptional activator of VEGF, has intricate mechanisms of nuclear translocation and activation, but its signal termination mechanism...

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Bibliographic Details
Main Authors: Lijie Dong, Wenbo Li, Tingting Lin, Boshi Liu, Yaru Hong, Xiaomin Zhang, Xiaorong Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
PSF
Hakai
VEGF
Neovascularization
HIF1-α
Hypoxia
Online Access:https://doi.org/10.1186/s12964-020-00684-w

Internet

https://doi.org/10.1186/s12964-020-00684-w

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