Remediating Desmoplasia with EGFR‐Targeted Photoactivable Multi‐Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer

Remediating Desmoplasia with EGFR‐Targeted Photoactivable Multi‐Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer

Abstract Desmoplasia is characteristic of pancreatic ductal adenocarcinoma (PDAC), which exhibits 5‐year survival rates of 3%. Desmoplasia presents physical and biochemical barriers that contribute to treatment resistance, yet depleting the stroma alone is unsuccessful and even detrimental to patien...

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Bibliographic Details
Main Authors: Girgis Obaid, Shazia Bano, Hanna Thomsen, Susan Callaghan, Nimit Shah, Joseph W. R. Swain, Wendong Jin, Xiadong Ding, Colin G. Cameron, Sherri A. McFarland, Juwell Wu, Mark Vangel, Svetla Stoilova‐McPhie, Jie Zhao, Mari Mino‐Kenudson, Charles Lin, Tayyaba Hasan
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Advanced Science
Subjects:
desmoplasia
molecular targeting
nanomedicine
pancreatic cancer
photodynamic therapy
Online Access:https://doi.org/10.1002/advs.202104594

Internet

https://doi.org/10.1002/advs.202104594

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