NMR Characterization of Angiogenin Variants and tRNA<sup>Ala</sup> Products Impacting Aberrant Protein Oligomerization

NMR Characterization of Angiogenin Variants and tRNA<sup>Ala</sup> Products Impacting Aberrant Protein Oligomerization

Protein oligomerization is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. Human Angiogenin (h-ANG), a ribonuclease A family member, produces RNA fragments that regulate ribosome formation, the creation of new blood ve...

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Bibliographic Details
Main Authors: Andrea Fagagnini, Miguel Garavís, Irene Gómez-Pinto, Sabrina Fasoli, Giovanni Gotte, Douglas V. Laurents
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
protein oligomerization
angiogenin (h-ANG)
tRNA
ALS
stress granules
NMR spectroscopy
Online Access:https://www.mdpi.com/1422-0067/22/3/1439

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https://www.mdpi.com/1422-0067/22/3/1439

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