RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m6A-dependent manner

RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m6A-dependent manner

Both genetic and microenvironmental detrimental factors are involved in ovarian dysfunction, leading to the increasing rate of involuntary childlessness in recent years. Oxidative stress (OS), which is characterized by the imbalance of redox system with redundant reactive oxygen species (ROS) overwh...

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Bibliographic Details
Main Authors: Hongbei Mu, Siying Cai, Xiaofei Wang, Huiying Li, Ling Zhang, Huaibiao Li, Wenpei Xiang
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
IGF2BP1
Granulosa cells
Oxidative stress
m6A modification
Cellular senescence
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002646

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http://www.sciencedirect.com/science/article/pii/S2213231722002646

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