Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required to combat malaria. P. falciparum parasites infect...

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Bibliographic Details
Main Authors: Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
P. falciparum
hemoglobin digestion
aminopeptidase
drug target
Online Access:https://elifesciences.org/articles/80813

Internet

https://elifesciences.org/articles/80813

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