Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis

Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis

BackgroundStimulation of IFN genes (STING) is central to the production of interferon and proinflammatory cytokines in response to microbial DNA or self-DNA in the cytosol. The detrimental role of the activation of STING during sepsis has been well documented.MethodsHere, we found that gelsevirine (...

Full description

Bibliographic Details
Main Authors: Yuhong Chen, Huihui Bian, Juan Lv, Wanxue Song, Chunlei Xing, Chunlei Hui, Dinglei Zhang, Chenxi Zhang, Liang Zhao, Yingke Li, Li Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
ubiquitination
cecal ligation and puncture
mice
interferon
septic shock
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190707/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190707/full

Similar Items