Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis-associated coagulopathy.MethodsIn this study, we...

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Bibliographic Details
Main Authors: Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Per H. Nilsson, Ole-Lars Brekke
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
platelet aggregation
glycoprotein IIb/IIIa
complement component C3
complement receptor 1
Escherichia coli
multiplate aggregometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020712/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020712/full

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