Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

Abstract Background Cyclosporin A (CsA) is a promising therapeutic drug for myocardial ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of mitochondrial permeability transition pore (mPTP). However, the application of cyclosporin A to treat MI/RI is limited due t...

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Bibliographic Details
Main Authors: Chang-xiong Zhang, Ying Cheng, Dao-zhou Liu, Miao Liu, Han Cui, Bang-le Zhang, Qi-bing Mei, Si-yuan Zhou
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Nanobiotechnology
Subjects:
Myocardial ischemia/reperfusion injury
Mitochondrial targeting
Cyclosporin A
Mitochondrial permeability transition pore
Mitochondria-targeted peptide
Online Access:http://link.springer.com/article/10.1186/s12951-019-0451-9

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http://link.springer.com/article/10.1186/s12951-019-0451-9

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