Catalase-deficient mice induce aging faster through lysosomal dysfunction

Catalase-deficient mice induce aging faster through lysosomal dysfunction

Abstract Background Lysosomes are a central hub for cellular metabolism and are involved in the regulation of cell homeostasis through the degradation or recycling of unwanted or dysfunctional organelles through the autophagy pathway. Catalase, a peroxisomal enzyme, plays an important role in cellul...

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Bibliographic Details
Main Authors: Raghbendra Kumar Dutta, Joon No Lee, Yunash Maharjan, Channy Park, Seong-Kyu Choe, Ye-Shih Ho, Hyug Moo Kwon, Raekil Park
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cell Communication and Signaling
Subjects:
Catalase
ROS
Aging
Lysosome
mTORC1
Online Access:https://doi.org/10.1186/s12964-022-00969-2

Internet

https://doi.org/10.1186/s12964-022-00969-2

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