Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution

Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution

BackgroundKidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying mechanisms driving alloimmune responses. Thus, und...

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Bibliographic Details
Main Authors: Ahmad Halawi, Abdullah B. El Kurdi, Katherine A. Vernon, Zhabiz Solhjou, John Y. Choi, Anis J. Saad, Nour K. Younis, Rania Elfekih, Mostafa Tawfeek Mohammed, Christa A. Deban, Astrid Weins, Reza Abdi, Leonardo V. Riella, Sasha A. De Serres, Paolo Cravedi, Anna Greka, Pierre Khoueiry, Jamil R. Azzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
graft rejection
kidney transplantation
single-cell analysis
cellular microenvironment
alloimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139358/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139358/full

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