Sulbactam Protects Hippocampal Neurons Against Oxygen-Glucose Deprivation by Up-Regulating Astrocytic GLT-1 via p38 MAPK Signal Pathway

Sulbactam Protects Hippocampal Neurons Against Oxygen-Glucose Deprivation by Up-Regulating Astrocytic GLT-1 via p38 MAPK Signal Pathway

Sulbactam is an atypical β-lactam medication and reported to be neuroprotective by up-regulating glial glutamate transporter-1 (GLT-1) in rats. The present study was undertaken to study the role of p38 MAPK signal pathway in sulbactam induced up-regulation of GLT-1 expression in astrocytes and anti-...

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Bibliographic Details
Main Authors: Jie Qi, Xiao-Hui Xian, Li Li, Min Zhang, Yu-Yan Hu, Jing-Ge Zhang, Wen-Bin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
sulbactam
p38 MAPK
GLT-1
astrocyte
OGD
neuron-astrocyte co-culture
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00281/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00281/full

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