Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?

Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?

Abstract Iron deficiency is common in idiopathic and heritable pulmonary arterial hypertension patients (I/HPAH). A previous report suggested a dysregulation of the iron hormone hepcidin, which is controlled by BMP/SMAD signaling involving the bone morphogenetic protein receptor 2 (BMPR‐II). Pathoge...

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Bibliographic Details
Main Authors: Vivienne Theobald, Ekkehard Grünig, Nicola Benjamin, Hans‐Jürgen Seyfarth, Michael Halank, Marc A. Schneider, Sarah Richtmann, Daniel Kazdal, Katrin Hinderhofer, Panagiota Xanthouli, Benjamin Egenlauf, Satenik Harutyunova, Marius M. Hoeper, Danny Jonigk, Richard Sparla, Martina U. Muckenthaler, Christina A. Eichstaedt
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Pulmonary Circulation
Subjects:
genetics
hepcidin
iron homeostasis
pulmonary vascular disease
Online Access:https://doi.org/10.1002/pul2.12242

Internet

https://doi.org/10.1002/pul2.12242

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