Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization

Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization

Background Perturbations in myocardial substrate utilization have been proposed to contribute to the pathogenesis of cardiac dysfunction in diabetic subjects. The failing heart in nondiabetics tends to decrease reliance on fatty acid and glucose oxidation, and increases reliance on ketone body oxida...

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Bibliographic Details
Main Authors: Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyopathy
diabetes mellitus
ketone metabolism
O‐GlcNAcylation
diabetic cardiomyopathy
glucose
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.013039

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.013039

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