Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2‐positive cancers

Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2‐targeted therapies improved progression‐free and overall survival in patients with HER2+ breast cancers. Howeve...

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Bibliographic Details
Main Authors: Lucas Blasquez, Haniaa Bouzinba‐Segard, Sandrine Bourdoulous, Camille Faure
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.13419