Dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose reduces endotoxemia-induced inflammation and oxidative stress: Implications in PAMP-associated acute and chronic pathology

Dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose reduces endotoxemia-induced inflammation and oxidative stress: Implications in PAMP-associated acute and chronic pathology

Pathogen-associated molecular patterns (PAMPs) like bacterial cell wall components and viral nucleic acids are known ligands of innate inflammatory receptors that trigger multiple inflammatory pathways that may result in acute inflammation and oxidative stress-driven tissue and organ toxicity. When...

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Bibliographic Details
Main Authors: Sanjay Pandey, Vandana Anang, Saurabh Singh, Saurabh Seth, Anant Narayan Bhatt, Namita Kalra, Kailash Manda, Ravi Soni, Bal Gangadhar Roy, K. Natarajan, Bilikere S. Dwarakanath
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
metabolism
pathogens
glycolysis
sepsis
chronic inflammation
neutrophils
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.940129/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.940129/full

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