Current understanding of CTLA-4: from mechanism to autoimmune diseases

Current understanding of CTLA-4: from mechanism to autoimmune diseases

Autoimmune diseases (ADs) are characterized by the production of autoreactive lymphocytes, immune responses to self-antigens, and inflammation in related tissues and organs. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is majorly expressed in activated T cells and works as a critical regulator in the i...

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Bibliographic Details
Main Authors: Md Munnaf Hossen, Yanmei Ma, Zhihua Yin, Yuhao Xia, Jing Du, Jim Yi Huang, Jennifer Jin Huang, Linghua Zou, Zhizhong Ye, Zhong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
CTLA-4
autoimmunity
regulatory T cell
autoimmune disease
immune regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1198365/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1198365/full

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