Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury

Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury

Vascular cognitive impairment is a major cause of dementia caused by chronic hypoxia, producing progressive damage to white matter (WM) secondary to blood-brain barrier (BBB) opening and vascular dysfunction. Tight junction proteins (TJPs), which maintain BBB integrity, are lost in acute ischemia. A...

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Bibliographic Details
Main Authors: Yi Yang, Shihoko Kimura-Ohba, Jeffrey F. Thompson, Victor M. Salayandia, Melissa Cossé, Limor Raz, Fakhreya Y. Jalal, Gary A. Rosenberg
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Neurobiology of Disease
Subjects:
Magnetic resonance imaging
Chronic hypoxia
BBB permeability
Tight junction proteins
Angiogenesis
Vascular cognitive impairment and dementia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300445

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http://www.sciencedirect.com/science/article/pii/S0969996118300445

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