MicroRNA-27b targets CBFB to inhibit differentiation of human bone marrow mesenchymal stem cells into hypertrophic chondrocytes

MicroRNA-27b targets CBFB to inhibit differentiation of human bone marrow mesenchymal stem cells into hypertrophic chondrocytes

Abstract Background Human bone marrow-derived mesenchymal stem cells (hBMSCs) have chondrocyte differentiation potential and are considered to be a cell source for cell-transplantation-mediated repair of cartilage defects, including those associated with osteoarthritis (OA). However, chondrocyte hyp...

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Bibliographic Details
Main Authors: Shuang Lv, Jinying Xu, Lin Chen, Haitao Wu, Wei Feng, Yangyang Zheng, Pengdong Li, Haiying Zhang, Lihong Zhang, Guangfan Chi, Yulin Li
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
hBMSCs
Chondrocytes
Hypertrophic differentiation
miR-27b
CBFB
RUNX2
Online Access:http://link.springer.com/article/10.1186/s13287-020-01909-y

Internet

http://link.springer.com/article/10.1186/s13287-020-01909-y

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