High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions

High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions

ABSTRACTThe urokinase-type plasminogen activator receptor (uPAR) is an essential regulator for cell signaling in tumor cell proliferation, adhesion, and metastasis. The ubiquitous nature of uPAR in many aggressive cancer types makes uPAR an attractive target for immunotherapy. Here, we present a rap...

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Bibliographic Details
Main Authors: André Luiz Lourenço, Shih-Wei Chuo, Markus F. Bohn, Byron Hann, Shireen Khan, Neha Yevalekar, Nitin Patel, Teddy Yang, Lina Xu, Dandan Lv, Robert Drakas, Sarah Lively, Charles S. Craik
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Antibody-dependent cellular cytotoxicity (ADCC)
cancer therapeutics
cross-reactive antibody
single B-cell screening
Urokinase-type plasminogen activator receptor (uPAR)
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2184197

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2184197

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