Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus

Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus

Objectives: Aberrant and persistent production of interferon-α (IFN-α) by plasmacytoid dendritic cells (pDCs) is known to play a key role in the pathogenesis of systemic lupus erythematosus (SLE). To assess the precise function of pDCs in SLE patients, we investigated the differential regulation of...

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Bibliographic Details
Main Authors: Kei Sakata, Shingo Nakayamada, Yusuke Miyazaki, Satoshi Kubo, Akina Ishii, Kazuhisa Nakano, Yoshiya Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
toll-like receptor 7
plasmacytoid dendritic cells
interferon-α
toll-like receptor 9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01957/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01957/full

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