STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice

STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice

Aberrant pro-inflammatory activation of Kupffer cells (KCs) is strongly involved in the pathogenesis of septic liver injury. Recent evidence indicates the crucial roles of excessive stimulator of interferon genes (STING) signaling activation during sepsis. However, the role of STING signaling in sep...

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Bibliographic Details
Main Authors: Qin Zhang, Jiayi Wei, Zhuanhua Liu, Xiaoxia Huang, Maomao Sun, Wujiang Lai, Zhenfeng Chen, Jie Wu, Yanjia Chen, Xiaohua Guo, Qiaobing Huang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Redox Biology
Subjects:
STING
DRP1
mtDNA
Kupffer cell
LPS
Liver injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001392

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http://www.sciencedirect.com/science/article/pii/S2213231722001392

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