Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis

The external granule layer (EGL) is a proliferative region that produces over 90% of the neurons in the cerebellum but can also malignantly transform into a cerebellar tumor called the medulloblastoma (the most common malignant brain tumor in children). Current dogma considers Hedgehog stimulation a...

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Autori principali: Kevin Kiyoshi Noguchi, Omar Hoseá Cabrera, Brant S. Swiney, Patricia Salinas-Contreras, Julie Kathryn Smith, Nuri B. Farber
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2015-11-01
Serie:Neurobiology of Disease
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Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996115300425