D-4F, an apolipoprotein A-I mimetic, suppresses IL-4 induced macrophage alternative activation and pro-fibrotic TGF-β1 expression

D-4F, an apolipoprotein A-I mimetic, suppresses IL-4 induced macrophage alternative activation and pro-fibrotic TGF-β1 expression

Context: We reported that D-4F, an apolipoprotein A-I (Apo A-I) mimetic polypeptide with 18 d-amino acids, suppressed IL-4 induced macrophage alternative activation and TGF-β1 expression in phorbol 12-myristate 13-acetate (PMA) treated human acute monocytic leukemia cells (THP-1). Objective: Macroph...

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Bibliographic Details
Main Authors: Xuejiao Song, Ying Shi, Jia You, Zhengshu Wang, Linshen Xie, Chaoxiong Zhang, Jingyuan Xiong
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Pharmaceutical Biology
Subjects:
apo a-i mimetic
thp-1
pulmonary fibrosis
monocyte-derived macrophages
m2 macrophage
Online Access:http://dx.doi.org/10.1080/13880209.2019.1640747

Internet

http://dx.doi.org/10.1080/13880209.2019.1640747

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