PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome

PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome

BackgroundWe performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing’s syndrome (CS) to define areas of dysregulated and druggable targets.MethodologyNext-generation sequencing was performed on adrenal samples of patients with primary bilateral macron...

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Bibliographic Details
Main Authors: Sharmilee Vetrivel, Mariangela Tamburello, Andrea Oßwald, Ru Zhang, Ali Khan, Sara Jung, Jessica E. Baker, William E. Rainey, Elisabeth Nowak, Barbara Altieri, Mario Detomas, Deepika Watts, Tracy Ann Williams, Ben Wielockx, Felix Beuschlein, Martin Reincke, Silviu Sbiera, Anna Riester
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Endocrinology
Subjects:
transcriptome
hypercortisolism
rosiglitazone
adrenocortical cell line
steroidome
cortisol
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1265794/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1265794/full

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