Celastrol Pyrazine Derivative Alleviates Silicosis Progression via Inducing ROS-Mediated Apoptosis in Activated Fibroblasts

Celastrol Pyrazine Derivative Alleviates Silicosis Progression via Inducing ROS-Mediated Apoptosis in Activated Fibroblasts

Silicosis is a complex occupational disease without recognized effective treatment. Celastrol, a natural product, has shown antioxidant, anti-inflammatory, and anti-fibrotic activities, but the narrow therapeutic window and high toxicity severely limit its clinical application. Through structural op...

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Bibliographic Details
Main Authors: Ying Bai, Chao Liang, Lu Gao, Tao Han, Fengxuan Wang, Yafeng Liu, Jiawei Zhou, Jianqiang Guo, Jing Wu, Dong Hu
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
silicosis
pulmonary fibrosis
celastrol derivative
fibroblast
apoptosis
Online Access:https://www.mdpi.com/1420-3049/29/2/538

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https://www.mdpi.com/1420-3049/29/2/538

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