Structure—yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates

Abstract Thirty-five 9-O-berberrubine carboxylate derivatives were synthesized and evaluated for yeast α-glucosidase inhibitory activity. All compounds demonstrated better inhibitory activities than the parent compounds berberine (BBR) and berberrubine (BBRB), and a positive control, acarbose. The s...

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Bibliographic Details
Main Authors: Duy Vu Nguyen, Kowit Hengphasatporn, Ade Danova, Aphinya Suroengrit, Siwaporn Boonyasuppayakorn, Ryo Fujiki, Yasuteru Shigeta, Thanyada Rungrotmongkol, Warinthorn Chavasiri
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45116-0