Optimization of an in vitro Pseudomonas aeruginosa Biofilm Model to Examine Antibiotic Pharmacodynamics at the Air-Liquid Interface

Abstract Pseudomonas aeruginosa is an important cause of lower respiratory tract infections, such as ventilator-associated bacterial pneumonia (VABP). Using inhaled antibiotics to treat VABP can achieve high drug concentrations at the infection site while minimizing systemic toxicities. Despite the...

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Bibliographic Details
Main Authors: Xing Tan, Yanqin Huang, Amisha Rana, Nidhi Singh, Taylor C. Abbey, Hui Chen, Peter T. Toth, Zackery P. Bulman
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-024-00483-y