circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p/PTPN1 axis

circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p/PTPN1 axis

Abstract Background Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and dysregulated circular RNA (circRNA) levels have been observed in the placentas of patients with GDM; however, the...

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Bibliographic Details
Main Authors: Runyu Du, Na Wu, Yu Bai, Lei Tang, Ling Li
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Translational Medicine
Subjects:
Circular RNA
circMAP3K4
Gestational diabetes mellitus
miR-6795-5p
Insulin resistance
Trophoblast cell
Online Access:https://doi.org/10.1186/s12967-022-03386-8

Internet

https://doi.org/10.1186/s12967-022-03386-8

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