A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter

A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter

The random non-standard peptide integrated discovery (RaPID) system has proven to be a powerful approach to discover de novo natural product-like macrocyclic peptides that inhibit protein functions. We have recently reported three macrocyclic peptides that bind to Pyrococcus furiosus multidrug and t...

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Bibliographic Details
Main Authors: Hiroaki Suga, Takayuki Katoh, Osamu Nureki, Christopher J. Hipolito, Yoshiki Tanaka
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
in vitro selection
cocrystallization ligand
random non-standard peptide integrated discovery (RaPID)
macrocyclic peptide
PfMATE
Online Access:http://www.mdpi.com/1420-3049/18/9/10514

Internet

http://www.mdpi.com/1420-3049/18/9/10514

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