Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

Hematopoiesis is regulated by the bone marrow (BM) stroma. However, cellular identities and functions of the different BM stromal elements in humans remain poorly defined. Based on single-cell RNA sequencing (scRNAseq), we systematically characterized the human non-hematopoietic BM stromal compartme...

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Bibliographic Details
Main Authors: Hongzhe Li, Sandro Bräunig, Parashar Dhapolar, Göran Karlsson, Stefan Lang, Stefan Scheding
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
hematopoietic microenvironment
human bone marrow
stromal stem/progenitor cells
single-cell RNA sequencing
differentiation hierarchy
hematopoietic-stromal communication
Online Access:https://elifesciences.org/articles/81656

Internet

https://elifesciences.org/articles/81656

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