Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1α axis and insulin sensitivity

Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1α axis and insulin sensitivity

Pyruvate dehydrogenase kinases (PDKs)-pyruvate dehydrogenase E1α subunit (PDHE1α) axis plays an important role in regulating glucose metabolism in mammals. However, the regulatory function of PDKs-PDHE1α axis in the glucose metabolism of fish is not well known. This study determined whether PDKs inh...

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Bibliographic Details
Main Authors: Yuan Luo, Wenhao Zhou, Ruixin Li, Samwel M. Limbu, Fang Qiao, Liqiao Chen, Meiling Zhang, Zhen-Yu Du
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-12-01
Series:Animal Nutrition
Subjects:
Dichloroacetate
Glucose utilization
Insulin sensitivity
Nile tilapia
PDK2/4-PDHE1α axis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405654522000798

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http://www.sciencedirect.com/science/article/pii/S2405654522000798

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