A dual-targeting ruthenium nanodrug that inhibits primary tumor growth and lung metastasis via the PARP/ATM pathway

A dual-targeting ruthenium nanodrug that inhibits primary tumor growth and lung metastasis via the PARP/ATM pathway

Abstract Background Many studies have found that ruthenium complexes possess unique biochemical characteristics and inhibit tumor growth or metastasis. Results Here, we report the novel dual-targeting ruthenium candidate 2b, which has both antitumor and antimetastatic properties and targets tumor si...

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Bibliographic Details
Main Authors: Yu Lu, Di Zhu, Lin Gui, Yuanming Li, Wenjing Wang, Jiawang Liu, Yuji Wang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Nanobiotechnology
Subjects:
Ruthenium
Self-assembly
Cell cycle
Apoptosis
Antitumor
Antimetastatic
Online Access:https://doi.org/10.1186/s12951-021-00799-3

Internet

https://doi.org/10.1186/s12951-021-00799-3

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