CRISPR/Cas9-Mediated Gene Correction in Osteopetrosis Patient-Derived iPSCs

CRISPR/Cas9-Mediated Gene Correction in Osteopetrosis Patient-Derived iPSCs

Background: Osteopetrosis represents a rare genetic disease with a wide range of clinical and genetic heterogeneity, which results from osteoclast failure. Although up to 10 genes have been identified to be related with osteopetrosis, the pathogenesis of osteopetrosis remains foggy. Disease-specific...

Full description

Bibliographic Details
Main Authors: Dandan Li, Minglin Ou, Wei Zhang, Qi Luo, Wanxia Cai, Chune Mo, Wenken Liang, Guandong Dai, Lianghong Yin, Peng Zhu, Donge Tang, Yong Dai
Format: Article
Language:English
Published: IMR Press 2023-06-01
Series:Frontiers in Bioscience-Landmark
Subjects:
crispr/cas9
gene correction
osteopetrosis
ipscs
clcn7
Online Access:https://www.imrpress.com/journal/FBL/28/6/10.31083/j.fbl2806131

Internet

https://www.imrpress.com/journal/FBL/28/6/10.31083/j.fbl2806131

Similar Items