High Dietary Phosphate Exacerbates and Acts Independently of Low Autophagy Activity in Pathological Cardiac Remodeling and Dysfunction

High Dietary Phosphate Exacerbates and Acts Independently of Low Autophagy Activity in Pathological Cardiac Remodeling and Dysfunction

High phosphate contributes to uremic cardiomyopathy. Abnormal autophagy is associated with the development and progression of heart disease. What is unknown is the effects of phosphate on autophagy and whether the ill effects of phosphate on cardiomyocytes are mediated by low autophagy. High (2.0% &...

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Bibliographic Details
Main Authors: Mingjun Shi, Sierra Shepard, Zhiyong Zhou, Jenny Maique, Olivia Seli, Orson W. Moe, Ming Chang Hu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
apoptosis
atg5
autophagy
cardiomyocyte
cardiomyopathy
phosphotoxicity
Online Access:https://www.mdpi.com/2073-4409/10/4/777

Internet

https://www.mdpi.com/2073-4409/10/4/777

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