Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q

Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q

Summary: Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of del(5q) have not been yet clarified. Methods: He...

Full description

Bibliographic Details
Main Authors: Vera Adema, Laura Palomo, Wencke Walter, Mar Mallo, Stephan Hutter, Thomas La Framboise, Leonor Arenillas, Manja Meggendorfer, Tomas Radivoyevitch, Blanca Xicoy, Andrea Pellagatti, Claudia Haferlach, Jacqueline Boultwood, Wolfgang Kern, Valeria Visconte, Mikkael Sekeres, John Barnard, Torsten Haferlach, Francesc Solé, Jaroslaw P. Maciejewski
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:EBioMedicine
Subjects:
Myelodysplastic syndromes
5q deletion
Haploinsufficiency
TP53
CSNK1A1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422002407

Internet

http://www.sciencedirect.com/science/article/pii/S2352396422002407

Similar Items