T-cell activation Rho GTPase-activating protein maintains intestinal homeostasis by regulating intestinal T helper cells differentiation through the gut microbiota

T-cell activation Rho GTPase-activating protein maintains intestinal homeostasis by regulating intestinal T helper cells differentiation through the gut microbiota

Common variants of the T-cell activation Rho GTPase-activating protein (TAGAP) are associated with the susceptibility to human inflammatory bowel diseases (IBDs); however, the underlying mechanisms are still unknown. Here, we show that TAGAP deficiency or TAGAP expression downregulation caused by TA...

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Bibliographic Details
Main Authors: Ruirui He, Jianwen Chen, Ziyan Zhao, Changping Shi, Yanyun Du, Ming Yi, Lingyun Feng, Qianwen Peng, Zhihui Cui, Ru Gao, Heping Wang, Yi Huang, Zhi Liu, Chenhui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
TAGAP
Akkermansia muciniphila
Bacteroides acidifaciens
Th17
colitis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1030947/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1030947/full

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