Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis

Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis

Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find that IL-12/23p40 promote...

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Bibliographic Details
Main Authors: Michelle A. Sallin, Shunsuke Sakai, Keith D. Kauffman, Howard A. Young, Jinfang Zhu, Daniel L. Barber
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
tuberculosis
Th1 cells
T-bet
terminal effector
T cell migration
IL-12
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303248

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http://www.sciencedirect.com/science/article/pii/S2211124717303248

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