Supralinear Dependence of the IP Receptor-to-Mitochondria Local Ca Transfer on the Endoplasmic Reticulum Ca Loading

Supralinear Dependence of the IP Receptor-to-Mitochondria Local Ca Transfer on the Endoplasmic Reticulum Ca Loading

Calcium signal propagation from endoplasmic reticulum (ER) to mitochondria regulates a multitude of mitochondrial and cell functions, including oxidative ATP production and cell fate decisions. Ca 2+ transfer is optimal at the ER-mitochondrial contacts, where inositol 1,4,5-trisphosphate (IP 3 ) rec...

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Bibliographic Details
Main Authors: György Csordás, David Weaver, Péter Várnai, György Hajnóczky
Format: Article
Language:English
Published: SAGE Publishing 2024-02-01
Series:Contact
Online Access:https://doi.org/10.1177/25152564241229273

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