The mitochondria-targeted derivative of the classical uncoupler of oxidative phosphorylation carbonyl cyanide m-chlorophenylhydrazone is an effective mitochondrial recoupler.
The synthesis of a mitochondria-targeted derivative of the classical mitochondrial uncoupler carbonyl cyanide-m-chlorophenylhydrazone (CCCP) by alkoxy substitution of CCCP with n-decyl(triphenyl)phosphonium cation yielded mitoCCCP, which was able to inhibit the uncoupling action of CCCP, tyrphostin...
| Prif Awduron: | , , , , , , , |
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| Fformat: | Erthygl |
| Iaith: | English |
| Cyhoeddwyd: |
Public Library of Science (PLoS)
2020-01-01
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| Cyfres: | PLoS ONE |
| Mynediad Ar-lein: | https://doi.org/10.1371/journal.pone.0244499 |