Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Abstract Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) engraftment is a promising therapy for acute ischemic stroke (AIS). However, the harsh ischemic microenvironment limits the therapeutic efficacy of hUC-MSC therapy. Curcumin is an anti-inflammatory agent that could impr...

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Bibliographic Details
Main Authors: Yuan Li, Jialu Huang, Jie Wang, Simin Xia, Hong Ran, Lenyu Gao, Chengjian Feng, Li Gui, Zhenhua Zhou, Jichao Yuan
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Human umbilical cord-derived mesenchymal stem cells
Curcumin
Anti-inflammatory phenotype microglia
AKT/GSK-3β/β-TrCP/Nrf2 axis
Online Access:https://doi.org/10.1186/s12974-023-02738-5

Internet

https://doi.org/10.1186/s12974-023-02738-5

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