Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Abstract Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) engraftment is a promising therapy for acute ischemic stroke (AIS). However, the harsh ischemic microenvironment limits the therapeutic efficacy of hUC-MSC therapy. Curcumin is an anti-inflammatory agent that could impr...

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Bibliographic Details
Main Authors:	Yuan Li, Jialu Huang, Jie Wang, Simin Xia, Hong Ran, Lenyu Gao, Chengjian Feng, Li Gui, Zhenhua Zhou, Jichao Yuan
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Series:	Journal of Neuroinflammation
Subjects:	Ischemic stroke Human umbilical cord-derived mesenchymal stem cells Curcumin Anti-inflammatory phenotype microglia AKT/GSK-3β/β-TrCP/Nrf2 axis
Online Access:	https://doi.org/10.1186/s12974-023-02738-5

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