Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using...

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Bibliographic Details
Main Authors: Qilei Yang, Chang Zu, Wengang Li, Weiwei Wu, Yunlong Ge, Lingling Wang, Li Wang, Yong Li, Xiuhua Zhao
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceutics
Subjects:
paclitaxel
antisolvent precipitation process
ionic liquids
bioavailability
Online Access:https://www.mdpi.com/1999-4923/12/11/1008

Internet

https://www.mdpi.com/1999-4923/12/11/1008

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