Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections

Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections

Protection against Plasmodium falciparum, which is primarily antibody-mediated, requires recurrent exposure to develop. The study of both naturally acquired limited immunity and vaccine induced protection against malaria remains critical for ongoing eradication efforts. Towards this goal, we deploye...

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Bibliographic Details
Main Authors: Madhura Raghavan, Katrina L Kalantar, Elias Duarte, Noam Teyssier, Saki Takahashi, Andrew F Kung, Jayant V Rajan, John Rek, Kevin KA Tetteh, Chris Drakeley, Isaac Ssewanyana, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Joseph L DeRisi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
antibodies
phage display
repeat regions
malaria
antigen profiling
natural immunity
Online Access:https://elifesciences.org/articles/81401

Internet

https://elifesciences.org/articles/81401

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