A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of Concern

A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of Concern

The prolonged duration of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has resulted in the continuous emergence of variants of concern (VOC, e.g., Omicron) and variants of interest (VOI, e.g., Lambda). These variants have challenged the protective efficacy of current COV...

Full description

Bibliographic Details
Main Authors: Lixiao Xing, Xinfeng Xu, Wei Xu, Zezhong Liu, Xin Shen, Jie Zhou, Ling Xu, Jing Pu, Chan Yang, Yuan Huang, Lu Lu, Shibo Jiang, Shuwen Liu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
SARS-CoV-2
variant of concern
fusion inhibitor
5-Helix
six-helix bundle
heptad repeat 1
Online Access:https://www.mdpi.com/1999-4915/14/3/597

Internet

https://www.mdpi.com/1999-4915/14/3/597

Similar Items