A lineage-tracing tool to map the fate of hypoxic tumour cells

A lineage-tracing tool to map the fate of hypoxic tumour cells

Intratumoural hypoxia is a common characteristic of malignant treatment-resistant cancers. However, hypoxia-modification strategies for the clinic remain elusive. To date, little is known on the behaviour of individual hypoxic tumour cells in their microenvironment. To explore this issue in a spatia...

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Bibliographic Details
Main Authors: Jenny A. F. Vermeer, Jonathan Ient, Bostjan Markelc, Jakob Kaeppler, Lydie M. O. Barbeau, Arjan J. Groot, Ruth J. Muschel, Marc A. Vooijs
Format: Article
Language:English
Published: The Company of Biologists 2020-07-01
Series:Disease Models & Mechanisms
Subjects:
hypoxia
lineage tracing
hif
cre recombinase
intravital imaging
nsclc tumour
Online Access:http://dmm.biologists.org/content/13/7/dmm044768

Internet

http://dmm.biologists.org/content/13/7/dmm044768

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