Genome-wide CRISPR/Cas9 screen reveals JunB downmodulation of HIV co-receptor CXCR4

Genome-wide CRISPR/Cas9 screen reveals JunB downmodulation of HIV co-receptor CXCR4

HIV-1 relies extensively on host cell machinery for replication. Identification and characterization of these host-virus interactions is vital to our understanding of viral replication and the consequences of infection in cells. Several prior screens have identified host factors important for HIV re...

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Bibliographic Details
Main Authors: William J. Schulze, Devon A. Gregory, Marc C. Johnson, Margaret J. Lange
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Microbiology
Subjects:
JunB
CXCR4
CRISPR/Cas9
HIV
host-factors
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342444/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342444/full

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