<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>

<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>

ABSTRACT The emergence and spread in Southeast Asia of Plasmodium falciparum resistance to artemisinin (ART) derivatives, the cornerstone of first-line artemisinin-based combination therapies (ACTs), underscore the urgent need to identify suitable replacement drugs. Discovery and development efforts...

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Bibliographic Details
Main Authors: Judith Straimer, Nina F. Gnädig, Barbara H. Stokes, Michelle Ehrenberger, Audrey A. Crane, David A. Fidock
Format: Article
Language:English
Published: American Society for Microbiology 2017-05-01
Series:mBio
Subjects:
K13/Kelch13
Plasmodium falciparum
artemisinin
drug resistance
fitness
gene editing
Online Access:https://journals.asm.org/doi/10.1128/mBio.00172-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00172-17

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