Direct Cardiac Actions of the Sodium Glucose Co‐Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure‐Overload Heart Failure

Direct Cardiac Actions of the Sodium Glucose Co‐Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure‐Overload Heart Failure

Background We determined if the sodium glucose co‐transporter 2 inhibitor empagliflozin attenuates pressure overload‐induced heart failure in non‐diabetic mellitus mice by direct cardiac effects and the mechanisms involved. Methods and Results Male C57BL/6J mice (4–6 months of age) were subjected to...

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Bibliographic Details
Main Authors: Xuan Li, Qingguo Lu, Yunguang Qiu, Jussara M. do Carmo, Zhen Wang, Alexandre A. da Silva, Alan Mouton, Ana C. M. Omoto, Michael E. Hall, Ji Li, John E. Hall
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac hypertrophy
cardiac metabolism
cardiomyocytes
sodium glucose cotransporter 2
transverse aortic constriction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018298

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.018298

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