Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis

Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis

The safe and effective use of Wnt signaling is a hot topic in developing osteogenic drugs. SB216763 (S33) is a widely used highly specific GSK3β inhibitor. Here, we show that S33 initiates canonical Wnt signaling by inhibiting GSK3β activity in the bone marrow stromal cell line ST2 and increases ost...

Full description

Bibliographic Details
Main Authors: Weimin Gong, Molin Li, Lizhou Zhao, Pengtao Wang, Xiaofang Wang, Bo Wang, Xing Liu, Xiaolin Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
SB216763
Wnt signaling
osteogenesis
adipogenesis
angiogenesis
PCL and cell integrated 3D scaffold
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1215233/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1215233/full

Similar Items