Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens are based on Monte Carlo simulation and has not...

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Bibliographic Details
Main Authors: Yichang Zhao, Huaiyuan Liu, Chenlin Xiao, Jingjing Hou, Bikui Zhang, Jiakai Li, Min Zhang, Yongfang Jiang, Indy Sandaradura, Xuansheng Ding, Miao Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
liver dysfunction
trough concentration
efficacy
therapeutic drug monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1323755/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1323755/full

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